[SA_Scat] CBMS Lecture Series - 22 September - Chris Brosey

[Stojanoff, Vivian]

Please join us ………..


Center for Biomolecular Structure Lecture Series



Incorporating HT-SAXS into Structure-Driven Drug Discovery Pipelines


Chris Brosey


M.D. Anderson Cancer Center, The University of Texas


WEDNESDAY, September 22, 13:30 (EST - NY time zone)



Register in advance for this meeting:

   https://bnl.zoomgov.com/meeting/register/vJIsfu6przwpH8NymLh_TKxtg09_NaMkFFs



Abstract:

High-throughput (HT) methods for discovering single-target protein and nucleic acid ligands are well established and routinely utilized for drug discovery. Many critical biological outcomes, however, are mediated by multi-component assemblies and dynamic macromolecular architectures. HT approaches to assess and fine-tune ligand impact on such functional, dynamic systems remain underdeveloped. Small-angle X-ray scattering (SAXS) provides an opportunity to monitor changes to biomolecular architectures and assemblies under native solution environments, enabling chemical screening and selection for specific architectural states. I will discuss how we have incorporated time-resolved HT-SAXS into a classic fragment screening pipeline and used this approach to identify chemical allosteric effectors targeting functional architectures of mitochondrial Apoptosis-Inducing Factor (AIF)

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Vivian Stojanoff, PhD
Education, Training, Outreach
User Program
p 1(631) 344 8375
e nsls.lifesciences at gmail.com<mailto:nsls.lifesciences at gmail.com>
w https://www.bnl.gov/ps/lifesciences/<https://www.bnl.gov/ps/lsbr/>

Address:
Center for Biomolecular Structure
National Synchrotron Light Source II
Building 745
Brookhaven National Laboratory
Upton NY 11973